Extraneous chemerin activates CMKLR1 and releases PTEN, then the recovered PTEN regains tumour suppressor activity and inhibits Akt, resulting in suppressed migration, invasion and metastasis of HCC cells, at least partially through downregulation of MMP1.25–27 This hypothesis is supported by our observation in clinical samples, HCC cells, and animal models of HCC metastasis. Here, RARRES2 is linked to hepatocellular carcinoma.