One study has shown that administration of ECI301, an active variant of the CC chemokine ligand 3, augmented the antitumour effect of radiofrequency ablation in a CCR1-dependent manner.28 In another study, administration of interleukin-12 was shown to enhance the therapeutic efficacy of dendritic cell-based tumour vaccines in moues hepatocellular carcinoma.29 In our study, administration of chemerin in HCC-bearing nude mice significantly restrained the development of both distant and intrahepatic metastasis. This evidence concerns the gene CCR1 and hepatocellular carcinoma.