In addition, GDF15-induced beneficial effects on myocardial infraction, atherosclerosis and obesity-related insulin resistance are associated with its anti-inflammatory actions such as reduction of neutrophil recruitment to myocardial lesions36 and a decrease of macrophage infiltration in atherosclerotic lesions37 and adipose tissue21. The gene discussed is GDF15; the disease is obesity due to melanocortin 4 receptor deficiency.