Consistent with Western blotting results, the expression level of G3BP1 was significantly higher in 51.2% (22/43) of the RCC samples, in contrast, G3BP1 expression was dramatically reduced to 25.6% (11/43) in para-tumor normal tissues (p = 0.0147, OR = 3.048, 95% CI 1.227–7.568), suggesting the expression level of G3BP1 in RCC tumors was markedly elevated as compared with the adjacent normal tissues. This evidence concerns the gene G3BP1 and renal cell adenocarcinoma.