Given the significance of G3BP1 in controlling IL-6/G3BP1/STAT3 signaling in RCC migration and metastasis in vitro, we next address the correlations of G3BP1 with IL-6 and STAT3 activation in our clinical study cohort comprising of 32 pairs of primary RCC and their corresponding adjacent normal kidney tissues. This evidence concerns the gene IL6 and renal cell adenocarcinoma.