Given the significance of G3BP1 in controlling IL-6/G3BP1/STAT3 signaling in RCC migration and metastasis in vitro, we next address the correlations of G3BP1 with IL-6 and STAT3 activation in our clinical study cohort comprising of 32 pairs of primary RCC and their corresponding adjacent normal kidney tissues. Here, STAT3 is linked to renal cell adenocarcinoma.