The results revealed that treatment of IL-6 (100 ng/ml) significantly (p < 0.01) promoted tumor cell migration (Fig. 4d) and invasion (Fig. 4e) in RCC ACHN cells, while G3BP1 depletion strongly attenuated the IL-6-induced enhancement of RCC cell migration and invasion (Fig. 4d, e). Here, IL6 is linked to renal cell carcinoma.