In line with this notion, we further treated G3BP1 knockdown and scramble control cells with human recombinant IL-6 (100 ng/ml) for 48 h, and Western blotting results revealed that stimulation with IL-6 did not only activate STAT3 but also induced G3BP1 expression in scramble RCC cells. The gene discussed is G3BP1; the disease is renal cell carcinoma.