The requirement for FZD8 in TGF-β signaling in prostate cancer is reminiscent of studies in lung fibroblasts, where TGF-β-induction of WNT5A, WNT5B, and FZD8 is required for the expression of genes encoding extracellular matrix proteins and myofibroblast differentiation markers58. This evidence concerns the gene WNT5A and prostate carcinoma.