The requirement for FZD8 in TGF-β signaling in prostate cancer is reminiscent of studies in lung fibroblasts, where TGF-β-induction of WNT5A, WNT5B, and FZD8 is required for the expression of genes encoding extracellular matrix proteins and myofibroblast differentiation markers58. This evidence concerns the gene FZD8 and Familial prostate cancer.