CASP3 and ovarian cancer: In agreement with activation of caspase-3, Piperine treatment triggered a dose-dependent proteolytic cleavage of PARP (a classical substrate of caspase-3), as evidenced by the accumulation of the characteristic 85 kDa fragments and a concomitant disappearance of the 115 kDa full-length PARP protein, further confirming the role of caspase-3 activation in the Piperine-induced apoptosis in ovarian cancer A2780 cells [39].