This region also binds the sequence-specific TFs FOXK1 and FOXK2 (65, 70), and exciting new results from the Berk laboratory demonstrate that single molecules of E1A must simultaneously form complexes with FOXK1/2, DCAF7, and CtBP during infection in order to suppress IRF3-driven activation of interferon (IFN)-stimulated genes (ISGs) (123). Here, FOXK1 is linked to infection.