TSC2 and hamartoma: In support of this notion, hamartomas associated with mutations in TSC1 or TSC2 (tuberous sclerosis complex 1 and 2) genes in humans (van Eeghen et al., 2012) have been phenocopied in zebrafish by the generation of mosaic embryos that carry wild-type and tsc2 (vu242/vu242) mutant cells (Kim et al., 2011).