PTEN and hamartoma: Strikingly, rapamycin treatment from P21 to P42 did not reduce hamartoma size in Pten cKOs, nor did it affect retinal morphology in wild-type or Pten cKOs (wild-type: 133±20 pixels; Pten cKO: 157±23 pixels, P=0.63; Fig. 5I-K).