PAX6 and PTEN hamartoma tumor syndrome: These lesions resembled the hamartomas characteristic of PHTS, and hereafter are referred to as hamartoma-like, whereas no such masses were detected in P21 wild-type animals (Fig. 1A) or in animals heterozygous for a Pten mutation (Ptenfl/+;Pax6::Cre+; data not shown).