HDAC6 and cancer: IP and Co-IP results for acetylated alpha tubulin with HDAC8, along with functional regulation studies of acetylation levels of alpha tubulin, under forskolin treated condition (phospho-form of HDAC8, known to be less active compared to control) reveals significant increase of acetylated tubulin expression, validating it as a novel substrate for HDAC8, in addition to HDAC6, which is an established tubulin and known to be a target in many of the cancers [36, 37].