In logistic regression analyses, controlling for demographics and other age-related pathologies, higher odds of dementia were observed in TDP-43 stages 3 (odds ratio 2.68, confidence interval 1.51-4.75, p < 0.001), 4 (odds ratio 1.90, confidence interval 1.05-3.42, p = 0.034) and 5 cases (odds ratio 5.20, confidence interval 2.23-12.1, p < 0.001) as compared to those without TDP-43 pathology (Table 3). This evidence concerns the gene TARDBP and dementia.