Given the propensity for TDP-43 pathology to affect the anterior and/or orbital frontal cortex (OFC) and temporal lobe structures with prominent neurodegeneration in FTLD-TDP, the hypothesis that TDP-43 pathology may also preferentially involve the anterior temporal pole cortex (ATPC) and OFC in aging and AD was tested. This evidence concerns the gene TARDBP and Alzheimer disease.