Nevertheless, the effect of specific cytolysis seemed independent of FLT3 expression level on leukemia cells but relied on whether they carried FLT3-ITD mutation, and the FLT3-ITD-positive leukemia cells were more sensitive to FLT3L-based CAR-T cells than the FLT3 wild-type leukemia cells. The gene discussed is FLT3; the disease is leukemia.