Analyzing NHERF1 reactivity at membrane level, its absence was observed in IDCs (p = 0.002) and positive lymph node status (p = 0.013); conversely mNHERF1 expression was significantly associated with tumor size ≤2 cm (p = 0.039) and MIB1 negative (p = 0.019). This evidence concerns the gene MIB1 and neoplasm.