Although in this work, by including the postprandial increase in the serum CA125 test, the CA125 cut-off was successfully lowered and the efficacy of early-stage ovarian cancer detection was accordingly improved, we still noted that there were cancer cases missed, even after adopting a postprandial increment-based diagnostic criterion with the highest efficacy (i.e., CA125 increment ≥ 10%). Here, MUC16 is linked to cancer.