Additionally, considering that a number of monocytes and resident macrophages may infiltrate the inflammatory cyst tissue [33], Siglec family proteins (i.e., Siglec-2, 7 and 9), which are an additional panel of monocyte/macrophage-specific CA125 receptors [34–36], may also skew the CA125 secretion/re-absorption balance toward a decrease in extracellular CA125. Here, MUC16 is linked to cyst.