We, herein, demonstrated that overexpressed Mesothelin mediates 1.1- to 19.4-fold greater CA125 re-absorption in insulin-treated cancer cells compared with that in control cells (Fig. 5e), while Mesothelin overexpression itself is also modulated by the PI3K-Akt pathway (Fig. 5a, b). The gene discussed is AKT1; the disease is cancer.