INS and ovarian cancer: Theoretically, insulin facilitates the recycling of GLUT4, a key glucose transporter, in ovarian cancer [28]; in turn, the accumulated intracellular glucose, through glycolysis and the Kreb’s cycle, offers an abundant reservoir of glucose-6-phosphate and energy molecules to the glycosyltransferase system that is responsible for CA125-core glycosylation [29, 30].