Since uptake of [18F]fluorodeoxy-glucose (18F-FDG) can be used to measure glucose consumption by aerobic and anaerobic glycolysis, 18F-FDG-positron emission tomography (18F-FDG-PET) was developed to exploit high glucose uptake/utilization by tumor cells, providing a clinically powerful tool for metabolic evaluation of many cancers, and useful for assessing on-target inhibition of the PI3K-Akt pathway [14, 18]. This evidence concerns the gene AKT1 and cancer.