Elevated expression of Nrf2 in the primary tumor was significantly associated with less differentiated histology (P <  0.0001), local invasion (P <  0.0001), lymph node metastasis (P = 0.0084), and LVI (P <  0.0001) (Table 1, Figs. 1b-e). The gene discussed is NFE2L2; the disease is metastatic malignant neoplasm in the lymph nodes.