Studies of Fujita et al. reported that the constitutively active NLR pyrin domain-containing protein 3 (NLRP3) inflammasome in human melanoma cells mediated autoinflammation via caspase-1 processing and IL-1β secretion [16] and NLRP1 inflammasome activation promoted tumor growth in metastatic melanoma [17]. The gene discussed is NLRP3; the disease is melanoma.