The mechanisms underlying this shift in NKX2.5 expression during thyroid cancer progression could involve many factors, such as changes in NKX2.5 sumoylation, which is known to regulate NKX2.5 [25], changes in the tumour microenvironment, changes in the expression of other transcription factor that could regulate NKX2.5, increased expression of miRNA targeting NKX2.5, among others. Here, NKX2-5 is linked to thyroid cancer.