WS is classified into four types (WS1, WS2, WS3 and WS4) with clinical and genetic hetero-geneses caused by mutations of six candidate genes, i.e., PAX3 (OMIM #606597), MITF (OMIM #156845), EDN3 (OMIM #131242), EDNRB (OMIM #131244), SOX10 (OMIM #602229) and SNAI2 (OMIM #602150) [1, 3]. This evidence concerns the gene MITF and Werner syndrome.