Among the 111 TFs in human blood lymphoblastoid cell lines, we identified 17 TFs, for example EED (enrichment fold = 4.80, p = 8.20E-5), RUNX3 (enrichment fold = 4.11, p = 2.03E-3), IKZF1 (enrichment fold = 4.33, p = 7.39E-4), and TCF12 (enrichment fold = 4.09, p = 2.50E-3) that significantly bind with psoriasis genetic variants (Fig 2 and S3 Table). The gene discussed is TCF12; the disease is psoriasis.