Importantly, this anti-correlation between MLL5 and H3K4me3 was only detected in primary glioblastoma cells with self-renewing potential, but not in bulk glioblastoma samples, nor in non-neoplastic brain samples or colon cancer cells (Gallo et al., 2015), indicating a regulatory process that is highly cell type specific. This evidence concerns the gene KMT2E and glioblastoma.