To elucidate the mechanism by which AICAR prevents the palmitate-stimulated MCP-1 secretion cascade (Figures 2(a)–2(c)), we first examined the involvement of NF-κB signaling, which has been characterized as an activator of the expressions of many genes and is considered to be crucial in obesity-induced inflammatory signaling [8, 16]. This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.