TNF and B-cell non-Hodgkin lymphoma: WHI evaluated 11 cytokines (IL1b, IL2, IL4, IL5, IL6, IL10, IL12, IL13, TNFα, IFNc, and GM-CSF) and found that subsequent risk of incident B-cell NHL in postmenopausal women (491 cases, 491 controls) was associated primarily with high levels of TNFα and IL10: ORs per doubling in serum cytokine concentration were 1.22 (95% CI = 1.07–1.38) for TNFα and 1.09 (95% CI = 1.04–1.15) for IL10 (51).