Therefore, complete suppression of thecell cycle and prevention of tumor growth via this mechanism require rapidcomplete inactivation of PTEN. This could apparently occur viathe suppression of PTENP1 pseudogene transcription throughmethylation of its promoter and/or depletion of ceRNA, whose function isperformed by PTENP1-sRNA. The gene discussed is PTENP1; the disease is neoplasm.