T1DM induced by chemical substances (STZ, alloxan, dithizone) is appropriatefor an evaluation of drugs or therapeutic approaches that decrease the bloodglucose level independently of β-cells; for example, for testing new insulin forms[54, 55].This model is also appropriate for assessing the effectiveness of transplantation therapythat also reduces the blood glucose level [56,57]. The gene discussed is INS; the disease is type 1 diabetes mellitus.