AlthoughGATA1–3 factors often serve as intermediaries in TAL1 binding to theregulatory sites of DNA in T-cell leukemia cells, there are alternative bindingsites, in particular Runx and Ets [59].It has been shown that the TAL1 transcription factor directly activates theexpression of Runx1, Ets1, and GATA3in the blast cells of patients with T-ALL[60]. Here, TAL1 is linked to acute lymphoblastic leukemia.