IFNG and coronary artery disorder: IFN-γ is a proinflammatory mediator that is believed to be the body’s main activator of monocytes and macrophages and more potent than any of the other interferons.3 Moreover, IFN-γ is also found in high levels in atherosclerotic plaques.3 While the 9p21 CHD susceptibility locus has also been linked with IFN-γ signalling, there are no known inhibitors for IFN-γ.