IL6 and coronary artery disorder: The findings for IL-6 are consistent with those of a previous meta-analysis of 17 prospective studies which reported OR (95% CI) of CHD of 1.61 (95% CI 1.42 to 1.83) per 2 SD increase in baseline IL-6.15 However, the latter study reported that the year-to-year variability of IL-6 values within individuals was relatively high (regression dilution ratios of 0.41; 95% CI 0.28 to 0.53, over 4 years, and 0.35; 95% CI 0.23 to 0.48, over 12 years) and, hence, the OR (95% CI) of CHD after correction for regression dilution bias was 3.34 (2.45 to 4.56).15