IFNG and coronary artery disorder: IL-5 and IFN-γ were also significantly associated with CHD after adjustment for established CHD risk factors, with an approximately 50% higher risk of CHD for individuals in the top versus the bottom third for IL-5 (OR 1.46; 95% CI 1.11 to 1.93; p<0.001) and IFN-γ (OR 1.46; 95% CI 1.09 to 1.95; p=0.01) levels, respectively.