The aims of the present analyses of the PROCARDIS case–control study were: (1) to study the inter-relationships of cytokines with each other and (2) to assess the independent relevance for CHD of plasma levels of five cytokines (IL-6, IL-5, IFN-γ, TNF-α and IL-6R) and of CRP before and after adjustment for established CHD risk factors. This evidence concerns the gene IL6 and coronary artery disorder.