IL‐22 has been shown to ameliorate steatosis and hepatic damage in acute ethanol feeding, chronic‐binge ethanol feeding and high‐fat diet‐induced fatty liver disease.128 This occurs with IL‐22 pretreatment in murine models of ALD.129, 130 Liver damage is also worse in IL‐22‐deficient (IL‐22 KO) mice.129, 130, 131 Conversely, in vivo and in vitro studies show liver regeneration or hepatocyte proliferation with overexpression of IL‐22.128, 132 Similarly, Ki et al. Here, IL22 is linked to steatosis.