Other models of sterile livery injury,114 where IL‐22 appears anti‐inflammatory/protective, include carbon tetrachloride (CCL4)‐ and FAS ligand (FASL)‐induced hepatic injury,137 and T‐cell‐mediated hepatitis induced by concanavalin A, where there was prevention of the hepatitis in IL‐22 pretreated mice compared with mice injected with IL‐22‐neutralising antibodies.51, 129 In general, the timing of an IL‐22 therapeutic intervention does not appear to be pro‐inflammatory where the injury model involved a sterile insult. Here, IL22 is linked to hepatitis A virus infection.