While IL‐22 appears to be associated with amelioration of liver injury in hepatic oxidative stress, alcohol‐induced liver injury or HFD models,76, 133, 134 HSCs were also associated with liver fibrogenesis and formation of scar tissue in response to chronic liver injury and expressed high levels of IL‐22R1.82 Specifically, IL‐22 administration induced HSCs and prevented their apoptosis in vivo and in vitro. The gene discussed is IL22; the disease is alcohol dependence.