In cerulein‐induced acute pancreatitis, IL‐22 appeared to be an anti‐inflammatory mediator due to its inhibition of inflammatory cell infiltrations mediated by the induction of Reg3 proteins in acinar cells.86 For example, on the one hand, injury was prevented via administration of recombinant IL‐22 (1ug/g) 2 hours prior the onset of the acute cerulean‐induced pancreatitis.87 (On the other hand, the injury of acute cerulein pancreatitis was not worse in IL‐22 KO mice;87 however, significant inflammatory cell infiltration was observed86). The gene discussed is REG3A; the disease is pancreatitis.