While serum IL‐22 directly correlates with disease activity of Crohn's disease, the lowest serum level was observed in carriers of the minor allele of the p.Arg381Gln mutation, which represents the only coding IL23R SNP and the main CD‐protecting IL23R variant.92 These findings taken together are consistent with an anti‐inflammatory role for IL‐22. This evidence concerns the gene IL22 and Crohn disease.