NFKB1 and diabetes mellitus: In a study by the Cai laboratory, diabetic OVE26 mice treated with MG132 displayed attenuated diabetes‐associated cardiac complications by upregulating Nrf2 activity and downstream antioxidant genes.132 In addition, MG123 functions to lessen inflammation by dampening the activation of the pro‐inflammatory transcription factor NF‐κB.