In a preclinical study using dh404, it could be demonstrated that diabetes‐associated atherosclerosis is significantly attenuated, along with reductions in pro‐inflammatory mediators, MCP‐1, vascular cell adhesion molecule 1 (VCAM‐1) and the p65 subunit of NF‐κB, suggesting that modulations of this pathway by pseudo‐stressors may be a feasible therapeutic strategy to lessen diabetes‐associated CVD.54, 55. This evidence concerns the gene NFKB1 and atherosclerosis.