The antioxidant TRX is inhibited by thioredoxin‐interacting protein (TXNIP) both of which have been shown to be upregulated in urine and peripheral blood mononuclear cells (PBMCs) from T1D patients with DN.72 In this setting, only TXNIP expression correlated with GFR decline. The gene discussed is TXNIP; the disease is liver dysplastic nodule.