NOX4 and type 1 diabetes mellitus: Recent studies have examined the use of a dual NOX1/NOX4 inhibitor (GKT137831) to prevent the development of DN65 in both early and delayed interventional T1D mouse models.64 These studies showed that inhibiting NOX1/NOX4 confers renoprotection by decreasing albuminuria, ROS production and glomerular macrophage infiltration.64, 65 Furthermore, this was associated with the decreased expression of pro‐inflammatory and pro‐fibrotic markers.