However, after examining the expression of CD68 (a general inflammatory macrophage marker) and CD163 (an M2 or anti‐inflammatory marker) in the glomerulus, there was a positive correlation with CD163+ cells and the severity of DN, whereas an inverse correlation was seen between renal function and CD68+ cells.66 Additionally, the observed correlation between the number of interstitial CD68+ macrophages and renal function indicated that macrophages play a role in DN progression.66 Since it is known that MCP‐1 can regulate recruitment of macrophages, a recent study by Boels et al. This evidence concerns the gene CCL2 and liver dysplastic nodule.