In animal models, genistein relieves neuropathic pain following nerve injury via downregulation of both IL-1β and IL-6 [40]; analgesic effect of coumarins is mediated by reducing spared nerve injury- (SNI-) induced upregulation of proinflammatory cytokines TNF-α, IL-1β, and IL-6 in damaged DRG [41]; bioactive fractions of annona reticulate bark attenuate painful diabetic neuropathy through decreasing the inflammatory cytokines (IL-1β, IL-6, and TNF-α) and increasing anti-inflammatory cytokine (IL-10) [42]. This evidence concerns the gene TNF and diabetic neuropathy.