On the other hand, the examination of the effects of environmental enrichment (large cages containing running wheel, colorful tunnels, and assorted toys) in transgenic AD mouse models showed controversial consequences in terms of amyloid deposition, with reduced Aβ levels and amyloid deposition in some investigations [11, 99] but neither decrease of amyloid or tau by studies of others [100, 101]. Here, MAPT is linked to Alzheimer disease.