For example, the persistent expression of the HBV x antigen (HBxAg) is correlated with the development of fibrosis and cirrhosis during CHB, as it can activate fibronectin-1 (FN-1) gene, through the induction of the nuclear factor kappa B (NF-kappa B or NFkB) (14). This evidence concerns the gene FN1 and Cirrhosis.