Furthermore, considering that IL-12 and IL-15 induced signals involve Jak2 and Tyk2 and Jak1/3 pathways, respectively, we decided to investigate the role of the specific Jak1/2 inhibitor ruxolitinib, a drug that has been approved for the treatment of myelofibrosis, in the generation of CIML NK cells. This evidence concerns the gene JAK1 and myelofibrosis.