Findings from these early studies led to three principles of exercise immunology being formed, which have, until now, generally been unchallenged in the literature: (i) infection risk is increased after an acute bout of prolonged and vigorous aerobic exercise; (ii) acute bouts of vigorous exercise can lead to a temporary reduction to salivary IgA levels culminating in a higher risk of opportunistic infections; and (iii) transient decreases in the number of peripheral blood immune cells, which occurs in the hours following vigorous exercise, represents a period of immune suppression. Here, CD79A is linked to infection.