The function of TCF7L2 in pancreas is well-studied using TCF7L2-overexpressing transgenic mice, Savic et al. (2011) have demonstrated robust glucose intolerance in multiple non-pancreatic tissues, including brain, stomach, intestine, and pancreas, and TCF7L2-null mice displayed improved glucose tolerance and lower insulin levels. This evidence concerns the gene INS and Glucose intolerance.