Indeed, converging evidence has recently showed that the protein kinase B (Akt)/GSK-3 and Wnt signaling pathways could play a key role in the pathogenesis of schizophrenia and the molecular mechanisms of APPs (Alimohamad et al., 2005a; Freyberg et al., 2010; Singh, 2013). This evidence concerns the gene AKT1 and schizophrenia.