PGP and neoplasm: In addition, multidrug-resistant CEM/ADR5000 cells with overexpression of various ABC transporters including P-gp/MDR1 (400-fold) (Kadioglu et al., 2016a) revealing high degrees of resistance to well-known anticancer drugs such as doxorubicin (1036-fold), vincristine (613-fold), docetaxel (435-fold), and many others (Efferth et al., 2008) were even slightly more sensitive to oridonin than the parental, wild-type, drug-sensitive CCRF-CEM tumor cells.