NFKB1 and malignant colon neoplasm: However, in HCT-1 colon cancer cell line treated with chelidonine [1], the NFκB activation was blocked by inhibition of IκBα degradation and nuclear translocation of p65 (an NFκB subunit) as well as mitogen-activated protein kinase pathway activation by blocking c-Jun N-terminal kinase and p38 phosphorylation (Zhang et al., 2018).