In particular, Vocca et al. [64] showed that the IL-33/ST2 axis might be involved in the progression of the various pathologies, influencing the generation of Th17 producing IL-31; they found very high serum levels of IL-31 and IL-33 in many inflammatory and autoimmune diseases, especially in lung illnesses [42, 64]. This evidence concerns the gene IL33 and autoimmune disease.