For example, it has been demonstrated that the receptors of the two cytokines, IL-31RA and ST2, are both expressed on dermal fibroblasts; it was hypothesized that IL-31 and IL-33 could synergistically stimulate chemokines in AD, supporting the involvement and the connection of both IL-31 and IL-33 in the various diseases, especially in AD [16]. This evidence concerns the gene IL31 and Alzheimer disease.