Angptl3 is primarily studied for its role in lipid and glucose metabolism21,22 and is involved in familial hypobetalipoproteinemia 2 (FHBL2), while Angptl4 has been reported to have wider but overlapping functions23 and has been implicated in wound repair24,25. Here, ANGPTL3 is linked to familial hypobetalipoproteinemia 2.