These animals were then used to determine the role of Piezo1 in mediating pressure-induced pancreatitis by subjecting tamoxifen-treated Ptf1a-CreER;Piezo1fl/fl (Piezo1aci KO) and Piezo1fl/fl (WT) mice to intrapancreatic duct pressure. The gene discussed is PIEZO1; the disease is pancreatitis.