We found LEC-induced changes in melanoma cells in the expression of ECM matrix components such as collagens, laminins, fibronectin and reelin; cell surface receptors such as integrins, TGF-beta receptors and platelet derived growth factor receptors; as well as actin cytoskeleton (Figure 2c, Supplementary file 2 related to Figure 2). This evidence concerns the gene RELN and melanoma.