NOTCH3 and carcinoma: MMP14, Notch3 and β1-integrin are all proteins linked to epithelial-to-mesenchymal transition in carcinoma cell metastasis (Cao et al., 2008; Kato et al., 2012; Liu et al., 2014), supporting the idea that the metastatic WM852* and WM165* melanoma cells have also undergone a transient transition into a more mesenchymally invasive state that can promote hematogenous dissemination.