IV delivery of HER2-BBz-CAR T cells at the dose that produced complete Daoy-GL tumor regression (Fig. 3b; Additional file 3: Figure S3b) was sufficient to eliminate D283-GL tumors, and both IT- and IV-delivered HER2-BBz-CAR T cells were significantly more effective than CD19-CAR T cells (Fig. 4b and c; Additional file 3: Figure S3c). The gene discussed is CD19; the disease is neoplasm.