In vivo, Daoy and D283 tumor cells were orthotopically implanted in the posterior fossa of NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice and treated with regional or intravenous HER2-BBz-CAR T cells or control CD19 CAR T cells. Here, ERBB2 is linked to neoplasm.