MET and hepatocellular carcinoma: Consistent to these findings, inhibition of MET and its downstream signaling by NZ001 was also only observed in the patients-derived HCC cells with MET-amplified and high MET/P-MET expression (Fig. 8b), pointing close association between inhibition of MET downstream signaling by NZ001 and MET-amplification and MET/P-MET high expression.