ICOS and neoplasm: Furthermore, LY3300054 also upregulated genes indicative of T cell activation (upregulated CD274, PDCD1LG2, IDO1, CXCL9, CXCL10, CD3E, CD8B, CD4, ICOS, CD27 etc) in tumor tissues collected from the established HCC827 tumor model implanted with ex vivo expanded human T cells and the co-implantation NCI-H292 model, although the overall effect of the antibody was less pronounced in these models compared to HCC827-bearing CD34+ hHSC-reconstituted NSG mice (Additional file 1: Figure S8).