Despite recent studies showing that PAPP-A and IGFBP-4 are potentially important biomarkers for the prediction of adverse outcomes in patients with acute coronary syndrome [11, 12], the evidence is scarce in contemporary-treated STEMI patients promptly reperfused, and to date, there are no reports on the prognostic value of Stanniocalcin-2 in this population. The gene discussed is PAPPA; the disease is acute coronary syndrome.