Several different mechanisms of azurin anticancer activity have been proposed: (i) induction of cancer cell apoptosis or growth inhibition by forming complexes with tumor protein p53; (ii) inhibition of cancer cell growth by interfering in the receptor tyrosine kinase EphB2-mediated signaling process; (iii) inhibition of tumor growth by preventing angiogenesis through reducing VEGFR-2 tyrosine kinase activity; (iv) interferention with P-cadherin protein expression and inhibition of the growth of breast cancer cells [124]. Here, EPHB2 is linked to cancer.