The PI3K/Akt signaling pathway plays a key role in insulin-stimulated GLUT4 glucose transporter translocation [1,3,4,5,6] and impairments in this cascade lead to reduced insulin-induced glucose transport into muscle cells contributing to insulin resistance and type 2 diabetes mellitus (T2DM) [1,4,7]. This evidence concerns the gene INS and type 2 diabetes mellitus.