In the present study, treatment of the cells with carnosol showed similar effects with that of metformin treatment in terms of glucose uptake stimulation (Figure 1C), AMPK activation (Figure 6A), and GLUT4 glucose transporter translocation (Figure 8A), all of which suggest a strong potential of carnosol to be used as metformin against insulin resistance and towards glucose homeostasis regulation. Here, SLC2A4 is linked to Insulin resistance.