In fact, treatment with aglycin led to similar results as those exerted by metformin in oral glucose tolerance (OGTT) and insulin tolerance tests [27]; furthermore, the release of insulin during OGTT was normal in the treated animals and, as expected, abnormal in T2D mouse controls, suggesting that the effect on glucose tolerance was primarily due to enhanced glucose uptake and insulin sensitivity [27]. This evidence concerns the gene INS and type 2 diabetes mellitus.