These findings support a role for immunogenetic factors in the occurrence of HLA-EUL40 responses upon HCMV infection and associate HLA-A*02/A*02 and HLA-E*01:01/HLA-E*01:03 genotypes as independent (p = 0.85) positive factors promoting HLA-EUL40 responses. The gene discussed is HLA-A; the disease is cytomegalovirus infection.