Infection of HeLa cells with recombinant THOV wild type (rTHOV-wt) as well as with the virus bearing TE mutation in ML (rTHOV-TE), which is still capable to bind TFIIB but cannot bind CAPN15, induced only minimal amounts of IFN-α/β (Fig 1D). The gene discussed is CAPN15; the disease is infection.