CEBPB and cancer: Taken together, here we show that loss-of-function mutation of a single cis-regulatory element - the uORF - in the Cebpb-mRNA, which prevents the translation into the transcription factor C/EBPβ-LIP, results in a remarkable juvenile phenotype in aged mice including lower cancer incidence, lower body weight and body fat, better glucose tolerance, lower memory/naïve T cell ratios, and better maintenance of motor coordination.