SHBG and polycystic ovary syndrome: In contrast, in PCOS womenfrom Korea, a significantly increased HDL-C level wasdetected in individuals carrying the variant allele (9).The small sample size of the studied PCOS patientgroup is the main limitation of the present study whichmay affect the association observed between PPARγ genotypesand PCOS, lipid and lipoprotein profiles, and estradioland SHBG levels.