Down-regulated genes common to CDD, MCDD and NASH were overrepresented in the GO terms “GO:0006629 Lipid metabolic process” and included the master lipid regulatorMlxipl and the lipid synthesis enzymesAcat2, Agpat2, Lss, Acacb andMvd. Here, LSS is linked to metabolic dysfunction-associated steatohepatitis.