These genes were also upregulated in MCDD and NASH, in which there were additional changes in fibrosis regulators (Lum,Osbpl3,Col6a3,Tgfbi,Tmsb10,Tpm1) and oncogenes (Golm1 andEmp1). This evidence concerns the gene COL6A3 and metabolic dysfunction-associated steatohepatitis.