BHMT and hepatocellular carcinoma: Some enzymes important in SAMe metabolism were dysregulated in the human HCC data (upregulated AHCY (LogFC 0.58); down-regulated BHMT (logFC-1.35), GNMT (LogFC -1.05) and MAT1a (logFC -0.97)), however these did not reflect the changes seen in the mouse model apart from a similar change in the expression of GNMT.