These genes were also upregulated in MCDD and NASH, in which there were additional changes in fibrosis regulators (Lum,Osbpl3,Col6a3,Tgfbi,Tmsb10,Tpm1) and oncogenes (Golm1 andEmp1). The gene discussed is OSBPL3; the disease is metabolic dysfunction-associated steatohepatitis.