Genes which were dysregulated in both MCDD and CDD datasets and in HCC were overrepresented in GO terms ‘GO:0000278 mitotic cell cycle’, ‘GO:0007599 Haemostasis’ and ‘GO:0070373 negative regulation of ERK1 and ERK2 cascade’ and include putative HCC oncogenesCdc20,Osgin1 andCdk1. The gene discussed is MAPK1; the disease is craniodiaphyseal dysplasia.